![]() The desire to extend preservation times has motivated research on optimal preservation solutions, temperatures, techniques, and therapeutic additives for organ repair and reconditioning 11, 12, 13, 14. In addition to being an excellent graft assessment tool, EVLP has also shown potential for enabling graft repair, reconditioning, and immunomodulation 7, which inspired similar research and clinical applications in other organ systems 8, 9, 10. ![]() Recently, the growing use of marginal organs from extended criteria donors has led to an emergence of ex vivo lung perfusion (EVLP) to assess donor lung function 5, 6. ![]() However, a number of limitations are associated with SCS, including tissue damage induced by prolonged hypothermic preservation, difficulty in assessing donor organ function and viability, inevitability of ischemia-reperfusion injury (IRI), and limited opportunity for organ repair. Static cold storage (SCS) offers a simple and effective way to preserve and transport organs and is the most commonly used method 4. It allows time for preparation of the recipient, organization of staff and facilities, allocation and transportation of the organ, and laboratory tests 2, 3. A supply of high-quality donor organs is crucial to transplantation procedures organ preservation has been described as “the supply line for organ transplantation” 1. A number of factors have contributed to the success of organ transplantation, including organ preservation, surgery, immunosuppressive medication, and post-transplantation care. Organ transplantation is the only effective therapy for patients with end-stage disease in many cases. This review describes the history of organ preservation, summarizes the progresses that has been made to date, and discusses future directions for organ preservation. The development of more sophisticated machine perfusion techniques and better perfusates may lead to organ repair/reconditioning. It is credited to its dynamic nature and physiological-like environment. Machine perfusion has resurfaced and dominates current research on organ preservation. Furthermore, the growing demand for the use of marginal donor organs requires methods for organ assessment and repair. However, preservation time with SCS is limited as prolonged cold storage increases the risk of early graft dysfunction that contributes to chronic complications. Currently, static cold storage (SCS) is the standard method for organ preservation. Preservation solutions and techniques are crucial for donor organ quality, which is directly related to morbidity and survival after transplantation. Organ transplantation is the most effective therapy for patients with end-stage disease.
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